newfangled condign

Tuesday, April 2, 2013

Newly identified tumor suppressor provides therapeutic target for prostate cancer

Apr. 1, 2013 ? Researchers have identified how an enzyme called PKC? (PKCzeta) suppresses prostate tumor formation. The finding, which also describes a molecular chain of events that controls cell growth and metastasis, could lead to novel ways to control disease progression.

Working in close collaboration, the labs of Maria T. Diaz-Meco, Ph.D., and Jorge Moscat, Ph.D., found that PKC? controls the activation of a pro-tumor gene called c-Myc. Normally, PKC?'s alteration keeps c-Myc in check. But PKC? levels are low in prostate and other cancers, leaving c-Myc free to enhance cell growth and metastasis. This study, appearing online April 2 in the Proceedings of the National Academy of Sciences, suggests that restoring PKC? could provide a new approach to treating prostate cancer.

How PKC? acts as a prostate tumor suppressor

Previous studies suggested that PKC? might act as a tumor suppressor -- but that wasn't clear in the case of prostate cancer. In their study, the team learned of PKC?'s role after genetically engineering mice so they lacked the enzyme altogether.

"In this study, we assessed the role of PKC? in prostate cancer, and for the first time we used a knockout mouse for PKC? to demonstrate that it's actually a tumor suppressor," Diaz-Meco said. "But, I think the major advance in this paper is that we found out how PKC? is a tumor suppressor in prostate cancer."

In their study, the researchers found that PKC? suppresses tumors in cooperation with a gene called PTEN. PTEN has been long known to act as a tumor suppressor, and it's also well-established that its mutated form is common in prostate cancer.

But the loss of normal PTEN function alone doesn't lead to aggressive prostate cancer. According to this study, the loss of PKC? and the resulting over-active c-Myc are also needed for aggressive prostate cancer to develop.

Potential approaches toward attacking prostate cancer may in the future involve activating PKC? through gene therapy, or dealing with its inaction downstream -- perhaps by finding another way to inhibit c-Myc in the absence of PKC?.

This research was funded by the U.S. National Institutes of Health (National Cancer Institute grants R01CA134530, R01CA132847, and 5P30CA030199-31; National Institute of Allergy and Infectious Diseases grant R01AI072581; National Institute of Diabetes and Digestive and Kidney Diseases grant R01DK088107) and the Department of Defense (grant DoD-PC080441).

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

Story Source:

The above story is reprinted from materials provided by Sanford-Burnham Medical Research Institute. The original article was written by Bruce Lieberman.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Ji Young Kim, Tania Valencia, Shadi Abu-Baker, Juan Linares, Sang Jun Lee, Tomoko Yajima, Jing Chen, Alexey Eroshkin, Elias A. Castilla, Laurence M. Brill, Mario Medvedovic, Michael Leitges, Jorge Moscat, and Maria T. Diaz-Meco. c-Myc phosphorylation by PKC? represses prostate tumorigenesis. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1221799110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/yQtUT01C0No/130401181504.htm

lyme disease symptoms esperanza spalding jessica sanchez robert kennedy cardinals san diego weather frances bean cobain

Suit says Huffington Post founder trashed NYC loft

FILE - This Feb. 24, 2013 file photo shows Arianna Huffington arrives at the 2013 Vanity Fair Oscars Viewing and After Partyl in West Hollywood, Calif. A lawsuit accuses Huffington Post founder Arianna Huffington of trashing a New York City loft that she leased from a documentary filmmaker. Huffington calls the allegations false. Filmmaker Eric Steel filed the suit in Manhattan Supreme Court on Monday, April 1. It asks for $275,000 in damages. The lawsuit says cabinets were broken and "the walls of the apartment were gouged, stained and otherwise damaged" during the two years Huffington rented the apartment. (Photo by Jordan Strauss/Invision/AP, file)

NEW YORK (AP) ? A lawsuit accuses Huffington Post founder Arianna Huffington of trashing a New York City loft that she leased from a documentary filmmaker.

Huffington calls the allegations false.

Filmmaker Eric Steel filed the suit in Manhattan Supreme Court on Monday. It asks for $275,000 in damages.

The lawsuit says cabinets were broken and "the walls of the apartment were gouged, stained and otherwise damaged" during the two years Huffington rented the apartment.

Under the terms of the lease agreement, Steel says Huffington was told she could not use the loft for business or parties.

The apartment was designed by Steel's stepfather, modernist architect Charles Gwathmey.

In a statement, Huffington says Steel "happily" renewed the lease twice and visited the apartment in Manhattan's Chelsea section. She says he has refused to return her $93,000 deposit.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-04-02-Huffington-Lawsuit/id-1175181e4d194c0390041a26da0ae075

dexter ny times paul mccartney Sandy Hook Victims new york times columbine breaking news

POLLS: Most Support Legal Immigration, But Want Border Secured ...

POLL:? Most people think legal immigration is good for the U.S., but want to see illegal immigrants who have overstayed their visas sent home

DENVER ? Most Americans believe that legal immigration is good for the country, but they want to see the border secured and illegal immigrants who have overstayed their visas removed from the country, according to Rasmussen Reports public opinion data.

When asked, ?Generally speaking, when done within the law, is immigration good for America or bad for America?? more than two-thirds of respondents (68 percent) said that such immigration was ?good? compared to fewer than one in five (19 percent) who said it was ?bad.?

Large majorities of both men (72 percent) and women (64 percent) agreed that legal immigration was good for the country, as did most Republicans (67 percent), Democrats (68 percent), and those who were not affiliated with either of the two major political parties (68 percent).

But public opinion data also reveals that most people want immigration officials to track down and deport the millions of foreigners who have overstayed their visas ? a group that experts suggest represents as many as half of the estimated 12 million illegal immigrants currently in the country.

When respondents were asked whether the federal government should find visa overstayers and make them go home, 55 percent of respondents said ?yes? compared to just 22 percent who said ?no.?? Another 23 percent were not sure.

A majority of men (64 percent) and a plurality of women (46 percent) support the deportation of visa overstayers.

Most white respondents (60 percent), as well as a plurality of both black respondents (42 percent) and those not identified as either black or white (43 percent), want to see visa overstayers sent home.

Older voters were more likely to back the removal of visa overstayers, but support was strong among voters of all age groups.

A plurality of respondents between 18 and 39 years of age backed sending overstays home (49 percent) as did a majority of those between the ages of 40 and 64 (58 percent) and those over 65 (57 percent).

Roughly two-thirds of Republicans (67 percent) and unaffiliated respondents (65 percent) also said they want to see those who have overstayed sent home.

Democrats, however, were more divided on the question; with 38 percent favoring sending overstays home, another 33 percent opposing such a policy, and 29 percent who were unsure.

Another Rasmussen survey question asked those who favor a plan to secure the border and grant legal status to illegal immigrants which should come first, a secure border or legal status for illegal immigrants?

Nearly two-thirds, 64 percent, said legal status should come only after the border is secure, compared to just 26 percent who said illegal immigrants should be given legal status right away.? Another 10 percent said they were not sure.

The view that border security should come before legal status for the estimated 12 million illegal aliens currently in the country had majority support among men (67 percent), women (60 percent), as well as Republicans (79 percent), Democrats (51 percent), and those unaffiliated with either of the two major political parties (67 percent).

The ?security first? approach was also popular with respondents in all age groups, with a majority of those between 18 and 29 years old (59 percent), 40 and 64 (63 percent), and those over 65 (72 percent) all backing a secure border before legal status for illegal immigrants.

A majority of white (66 percent) and black (64 percent) respondents also backed a stricter approach, as did half of those who did not identify themselves as either black or white (50 percent).

The Rassmussen Reports national polls surveyed 1,000 likely voters between March 20 and March 21, and has a margin of error of + / ? 3 percentage points.

Source: http://thecoloradoobserver.com/2013/04/polls-most-support-legal-immigration-but-want-border-secured-and-visa-overstayers-sent-home/?utm_source=rss&utm_medium=rss&utm_campaign=polls-most-support-legal-immigration-but-want-border-secured-and-visa-overstayers-sent-home

punxsutawney egypt soccer riot facebook ipo facebook ipo mike kelley puxatony phil josh harvey clemons

Monday, April 1, 2013

South Korea vows fast response to North; U.S. deploys stealth jets

By Jack Kim

SEOUL (Reuters) - South Korea will strike back quickly if the North stages any attack, the new president in Seoul warned on Monday, as tensions ratcheted higher on the Korean peninsula amid shrill rhetoric from Pyongyang and the U.S. deployment of radar-evading fighter planes.

North Korea says the region is on the brink of a nuclear war in the wake of United Nations sanctions imposed for its February nuclear test and a series of joint U.S. and South Korean military drills that have included a rare U.S. show of aerial power.

The North, whose economy is smaller than it was 20 years ago, appeared to move on Monday to addressing its pressing need for investment by appointing a reformer to the country's ceremonial prime minister's job, although the move mostly cemented a power grab by the ruling Kim clan.

North Korea had said on Saturday it was entering a "state of war" with South Korea in response to what it termed the "hostile" military drills being staged in the South. But there have been no signs of unusual activity in the North's military to suggest an imminent aggression, a South Korean defense ministry official said last week.

"If there is any provocation against South Korea and its people, there should be a strong response in initial combat without any political considerations," President Park Geun-hye told the defense minister and senior officials at a meeting on Monday.

The South has changed its rules of engagement to allow local units to respond immediately to attacks, rather than waiting for permission from Seoul.

Stung by criticism that its response to the shelling of a South Korean island in 2010 was tardy and weak, Seoul has also threatened to target North Korean leader Kim Jong-un and to destroy statues of the ruling Kim dynasty in the event of any new attack, a plan that has outraged Pyongyang.

Seoul and its ally the United States played down Saturday's statement from the official KCNA news agency as the latest in a stream of tough talk from Pyongyang.

North Korea stepped up its rhetoric in early March, when U.S. and South Korean forces began annual military drills that involved the flights of U.S. B-2 stealth bombers in a practice run, prompting the North to puts its missile units on standby to fire at U.S. military bases in the South and in the Pacific.

The United States also deployed F-22 stealth fighter jets on Sunday to take part in the drills. The F-22s were deployed in South Korea before, in 2010.

On its part, North Korea has cancelled an armistice agreement with the United States that ended the Korean War and cut all hotlines with U.S. forces, the United Nations and South Korea.

NUCLEAR WEAPONS "NOT A BARGAINING CHIP"

Park's intervention came on the heels of a meeting of the North's ruling Workers Party Central Committee where leader Kim Jong-un rejected the notion that Pyongyang was going to use its nuclear arms development as a bargaining chip.

"The nuclear weapons of Songun Korea are not goods for getting U.S. dollars and they are ... (not) to be put on the table of negotiations aimed at forcing the (North) to disarm itself," KCNA news agency quoted him as saying.

At the meeting, Kim appointed a handful of personal confidants to the party's politburo, further consolidating his grip on power in the second full year of his reign.

The most surprising appointment came on Monday as former prime minister Pak Pong-ju was re-appointed as premier, although the move likely signaled another power struggle in Pyongang staged by the country's leader Kim Jong-un.

Pak is viewed as a key ally of Jang Song-thaek, the young Kim's uncle and also a protege of Kim's aunt and is viewed as a pawn in a power game that has seen Jang and his wife re-assert power over military leaders.

Analysts said the move would not likely change Pyongyang's approach to a confrontation that appears to have dragged the two Koreas closer to war.

Pyongyang's on-off negotiations saw it take part in nuclear disarmament talks for five years aimed at paying it off in return for abandoning its atomic weapons program. Those talks fell apart in 2008. Some experts say the talks gave the North grounds to pursue a highly enriched uranium program that took it closer to owning a working arsenal.

Songun is the Korean word for the "Military First" policy preached by Kim's father who used it to justify the use of the impoverished state's scare resources to build a 1.2-million strong army and a weapons of mass destruction program.

CALLS FOR RESTRAINT

White House National Security Council spokeswoman Caitlin Hayden said North Korea's announcement that it was in a state of war followed a "familiar pattern" of rhetoric.

China has repeatedly called for restraint on the peninsula.

However, many in South Korea have regarded the North's willingness to keep open the Kaesong industrial zone, located just a few miles (km) north of the heavily-militarized border and operated jointly by both sides, as a sign that Pyongyang will not risk losing a lucrative source of foreign currency.

Closure could also trap hundreds of South Korean workers and managers of the more than 100 firms that have factories there.

(Additional reporting by Paul Eckert in WASHINGTON; Editing by David Chance, Raju Gopalakrishnan, Ian Geoghegan and Ron Popeski)

Source: http://news.yahoo.com/south-korea-vows-fast-response-north-u-deploys-043826040.html

Election results 2012 exit polls Presidential Polls California Propositions Electoral College chuck pagano A Gay Lesbian

Death penalty decision expected in James Holmes case

James Holmes sits with defense attorney Tamara Brady during his arraignment on March 12. (AP)

DENVER ? James Holmes, the man accused of shooting 70 people, killing 12, during a midnight attack at an Aurora, Colo., movie theater last summer, will likely learn Monday whether he?ll face execution if convicted.

Prosecutors from the Arapahoe County District Attorney?s office plan to announce in a 9 a.m. MT hearing if they?ll seek the death penalty, should the case go to trial. Monday?s decision follows last week?s legal theatrics in which Holmes? defense team said it would enter a guilty plea if the district attorney settled on a life-in-prison sentence.

?It is Mr. Holmes? position that this case could be resolved on April 1,? his public defenders announced last Wednesday in court filings posted online by the Denver Post. ?Mr. Holmes made an offer to the prosecution to resolve this case by pleading guilty and spending the rest of his life in prison, without any opportunity for parole.?

Not only did prosecutors decline the guilty offer?first made prior to Holmes? March 12 arraignment?but they also lambasted the defense for making it public.

In a 13-page rebuttal to the defense, the prosecution dubbed the public announcement ?grossly improper? and ?a calculated attempt to improperly inject? the plea in front of the Aurora community and the world. The prosecution also accused the Colorado public defenders office of violating the court?s order on pretrial publicity.

Because of the defense?s public plea, ?[t]he only conclusion that [people] would reach ... is that the defendant knows that he is guilty, the defense attorneys know that he is guilty, and that both of them know that he was not criminally insane,? the prosecution?s filing said.

Judge William Sylvester has scheduled the trial for four weeks starting Aug. 5. But the defense said that if the prosecution doesn?t accept the guilty plea, the trial could last months and could be delayed by multiple pretrial motions. At the March arraignment, defense attorney Daniel King said a trial without the specter of the death penalty could take as little as three weeks. But if execution is sought, King said they?d mount a vigorous defense based on an insanity strategy.

A mental health defense would be central to Holmes? case, his attorneys have implied repeatedly. Nearly all courtroom argument so far has revolved around his mental state, with the prosecution alleging that Holmes carefully crafted a ?detailed and complex? scheme to commit mass murder?with his sanity fully intact.

At the arraignment, King told Sylvester that Holmes wasn?t ready to enter a plea because the defense didn?t know whether the prosecution wanted to pursue the death penalty. The judge then entered a not-guilty plea on Holmes? behalf, as allowed by law.

Also at Monday?s hearing, Jana Winter, a Fox News reporter, is expected to testify about conversations she had with sources who gave her information for a story she wrote a few days after the July 20, 2012, theater massacre. Her story included details about an unopened package that Holmes mailed to the University of College at Denver. Winter, quoting unnamed law enforcement officials, reported that Holmes sent his former psychiatrist a notebook containing drawings that foreshadowed the July 20 attack. Because of a court gag order, those law enforcement sources were prevented from talking to the media.

Holmes? attorneys have argued that by divulging details to Winter, the two sources damaged the defendant?s right to a fair trial. Winter, through her attorney, has on multiple occasions tried to avoid appearing in court and has appealed the subpoena in New York state. Sylvester has denied her motions.

Holmes, 25, was a former neuroscience student at UC-Denver before the massacre at the premiere of ?The Dark Knight Rises,? the latest Batman movie. Police arrested Holmes, who was wearing body armor and had weapons close by, behind the theater shortly after the shootings. Police say he also booby-trapped his nearby Aurora apartment with explosives to injure or kill anyone who entered. He faces multiple counts of murder and attempted murder.

Source: http://news.yahoo.com/blogs/lookout/death-penalty-decision-expected-james-holmes-case-113742034.html

drudge report Presidential Election 2012 Incumbent politico Tammy Baldwin house of representatives paul ryan

Swish Navigates SFTP Connections in Windows Explorer

Swish Navigates SFTP Connections in Windows Explorer Windows: Opening up a dedicated FTP client just to find a file or two is a pain. Swish integrates your SFTP connections directly into Windows Explorer to save you the trouble.

Swish will install as a Windows Explorer extension and show up as a mounted drive on your system. Within this drive, you can add SFTP connections, and navigate them within Explorer. You'll need to put in your password the first time you connect, but it will save it thereafter to make navigation even faster.

Unfortunately, Swish only works with SFTP connections, not FTP, WebDAV, or cloud storage services like most FTP clients support. If that's all you need though, this will essentially replace any need you have for a standalone client.

Swish (Free) via MakeUseOf

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/XfEl_4QT3WM/swish-navigates-sftp-connections-in-windows-explorer

foo fighters nikki minaj album of the year grammy red carpet grammy award winners the band perry grammy awards

Pope leads Catholics into Easter at vigil service in St. Peter's

By Philip Pullella

VATICAN CITY (Reuters) - Pope Francis, leading the world's 1.2 billion Catholics into Easter for the first time, on Saturday urged those who have strayed from the faith to allow God back into their lives.

Francis, who was elected on March 13, presided at a solemn Easter vigil Mass in St. Peter' Basilica to usher the Catholic Church into the most important day of its liturgical calendar.

The immense basilica, the largest church in Christendom, was in the dark for the start of the service to signify the darkness in Jesus' tomb before what Christians believe was his resurrection from the dead three days after his crucifixion.

Some 10,000 faithful lit candles as Francis, the former Cardinal Jorge Bergoglio of Argentina, walked up the main aisle, and then the basilica's lights were turned on.

The 76-year-old Francis, wearing relatively plain white vestments - as opposed to the more elaborate robes preferred by his predecessor Benedict - delivered a simple homily recounting the Bible story of the women who went to Jesus' tomb but were surprised to find it empty.

He urged his listeners not to be "afraid of God's surprises," never to lose confidence during the trials and tribulations of daily life, and, if they have strayed, to let God back into their lives.

"Let the risen Jesus enter your life, welcome him as a friend, with trust: he is life! If up till now you have kept him at a distance, step forward. He will receive you with open arms," he said, speaking in Italian.

"If you have been indifferent, take a risk: you won't be disappointed. If following him seems difficult, don't be afraid, trust him, be confident that he is close to you, he is with you and he will give you the peace you are looking for and the strength to live as he would have you do," he said.

Another difference between Francis and his predecessor is that Francis reads his homilies standing behind a lectern like an ordinary priest instead of while seated on a throne.

He is still living in the same Vatican guesthouse where he stayed during the conclave that elected him the first non-European pope in 1,300 years instead of moving into the spacious and regal papal apartments in the Vatican's Apostolic Palace.

Francis has also been inviting ordinary people to his morning Mass at the guesthouse, including Vatican street sweepers and gardeners and staff of the guest house.

During Saturday night's service he presided at another Easter vigil tradition by baptizing four new adult members of the Church. They were from Italy, Albania, Russia and the United States.

Holy Saturday was the third of four hectic days leading up to Easter Sunday, the most important day in the Christian liturgical calendar.

On Easter Sunday he will celebrate another Mass and then deliver his first "Urbi et Orbi" (to the city and the world) message from the central balcony of St. Peter's Basilica to tens of thousands of people in the square below.

The balcony is the same spot where he first appeared to the world as pope on the night of March 13 after his election.

(Reporting By Philip Pullella; Editing by Jason Webb)

Source: http://news.yahoo.com/pope-leads-catholics-easter-vigil-st-peters-214300576.html

nevada caucus ufc 143 what time does the super bowl start ben gazzara nfl hall of fame 2012 ufc diaz vs condit josephine baker